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Genome-wide association study identifies 74 loci associated with educational attainment #
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약 40만명의 유전자형과 교육받은 기간을 GWAS하여 74개의 관련 유전좌위 확인 - 관련유전자들은 태아 뇌에서 불균형하게 발현되며, 신경계 발달과 관련된다.

관련정보 #

포함된 코호트 (일부)

  • deCODE (46,758)
  • 23andMe (76,155)
  • LifeLines (네덜란드, 12,539)
  • HRS (미국, 9,963)
  • STR-Twingenes (스웨덴, 9,553)
  • QIMR (호주, 8,006)

사용된 소프트웨어

관련 유전자 목록

  • TBR1 - Developmental biology, decreased brain size, abnormal cerebral cortex morphology
  • MEF2C - ERBB signalling pathway, abnormal sternum ossi cation, regulation of muscle cell differentiation
  • ZSWIM6 - Transcription factor binding, negative regulation of signal transduction, PI3K events in ERBB4 signalling
  • BCL11A - Dendritic spine organization, abnormal hippocampal mossy bre morphology, SWI/SNF-type complex
  • CELSR3 - Dendrite morphogenesis, dendrite development, abnormal hippocampal mossy bre morphology
  • MAPT - Dendrite morphogenesis, abnormal hippocampal mossy bre morphology, abnormal axon guidance
  • SBNO1 - Protein serine/threonine phosphatase complex
  • NBAS
  • NBEA - Developmental biology, signalling by Robo receptor, dendritic shaft
  • SMARCA2
  • MAP4 - Developmental biology, signalling by Robo receptor, SWI/SNF-type complex
  • LINC00461 - Decreased brain size, abnormal cerebral cortex morphology, abnormal hippocampal mossy bre morphology
  • POU3F2 - Dendrite morphogenesis, developmental biology, decreased brain size
  • RAD54L2 - Decreased brain size, SWI/SNF-type complex, nBAF complex
  • PLK2 - Negative regulation of signal transduction, PI3K events in ERBB4 signalling

토론 #

나의 23andMe 결과 보고 내 유전자형은 어떤가 살펴볼까 했더니만 (사실 알고싶진 않은데 뭐 관련분야니까), 이미 연구 코호트에 23andMe가 포함되어 있네. 조만간, 저 사이트에서 지능 점수 뭐 이런거 보여줄 듯. Hyungyong Kim, 2016-05-13

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