It in necessary for cellular transformation and cancer progression in Leukemias containg these fusion proteins.
SET domain이 없는 Lysine methyltransferase 임.
Methylation of H3K79 by DOT1L occurs in the globular domain of nucleosomal histone H3
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- DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression