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DOT1-like, Histone H3 methyltransferase Histone methylation enzyme. ( (other alias: KMT4) class I-like SAM-binding methyltransferase

It in necessary for cellular transformation and cancer progression in Leukemias containg these fusion proteins.

SET domain이 없는 Lysine methyltransferase 임.

Methylation of H3K79 by DOT1L occurs in the globular domain of nucleosomal histone H3

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