SET and MYND domain-containing protein 3 (Smyd3, KMT3E) is a protein that in humans is encoded by the SMYD3 gene. SMYD3 is a Histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex. (https://en.wikipedia.org/wiki/SMYD3)

H3K4, H3K5를 메틸화하여 activator 역할

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• Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development

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