Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development
#
Find similar titles
- (rev. 2)
- Hyungyong Kim
Structured data
- About
- SMYD3
- Date Published
- Publisher
- Cancer Cell
- URL
- http://www.ncbi.nlm.nih.gov/pubmed/26908355
Smyd3는 Cancer development와 관련된 protein methyltransferase. 쥐에서의 Smyd3 발현은 liver, 화학적으로 유도된 colon cancer formation을 필요로 한다. 이들 기관에서 Cell proliferation, EMT, AK-STAT signaling pathway와 관련된 핵심 조절자들의 전사를 촉진한다.
Smyd3은 H3K4Me3-modified histone tail과 상호작용하여 대부분 유전자의 활성을 촉진한다.
타겟 유전자에 대한 Smyd3 binding density는 RNA pol2 density와 상관관계가 있다.
원희영 저널 발표
Table of Contents
Summary #
Introduction #
Results #
Smyd3 Inactivation Protects against Chemically Induced HCC and CRC Development #
Smyd3 Is Dispensable for Carcinogen-Induced Cell Death and Inflammation, but Is Required for Compensatory Cell Proliferation #
Smyd3 Regulates Oncogene Activation and Epithelial to Mesenchymal Transition #
Smyd3 Potentiates the RNA Pol-II-Mediated Transcription of Cancer-Promoting Genes #
The Mechanism of Target Gene Selection by Smyd3 Involves Interaction with Trimethylated H3K4 Tails #
Discussion #
Suggested Pages #
- 0.025 Histone methylation
- 0.025 H3K4
- 0.025 H3K5
- 0.025 Hyuna Kim
- 0.013 PRMT5
- 0.013 SMYD5
- 0.013 Hyungyong Kim
- 0.013 SET7
- 0.013 June 18
- 0.013 KMT6B
- More suggestions...