Skip to content

Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development #
Find similar titles

Structured data

Date Published
Cancer Cell

Smyd3는 Cancer development와 관련된 protein methyltransferase. 쥐에서의 Smyd3 발현은 liver, 화학적으로 유도된 colon cancer formation을 필요로 한다. 이들 기관에서 Cell proliferation, EMT, AK-STAT signaling pathway와 관련된 핵심 조절자들의 전사를 촉진한다.

Smyd3H3K4Me3-modified histone tail과 상호작용하여 대부분 유전자의 활성을 촉진한다.

타겟 유전자에 대한 Smyd3 binding density는 RNA pol2 density와 상관관계가 있다.

원희영 저널 발표

Summary #

Introduction #

Results #

Smyd3 Inactivation Protects against Chemically Induced HCC and CRC Development #

Smyd3 Is Dispensable for Carcinogen-Induced Cell Death and Inflammation, but Is Required for Compensatory Cell Proliferation #

Smyd3 Regulates Oncogene Activation and Epithelial to Mesenchymal Transition #

Smyd3 Potentiates the RNA Pol-II-Mediated Transcription of Cancer-Promoting Genes #

The Mechanism of Target Gene Selection by Smyd3 Involves Interaction with Trimethylated H3K4 Tails #

Discussion #

Suggested Pages #