BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells
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- (rev. 1)
- Hyungyong Kim
Structured data
- About
- Triple-negative breast cancer
- BCL11A
- Date Published
- Publisher
- Nature Communications
- URL
- http://www.ncbi.nlm.nih.gov/pubmed/25574598
Transcription factor BCL11A가 TNBC에서 과발현되거나 증폭됨. 이는 tumor formation을 촉진하는 반면, 이것의 knockdown은 암을 저해함.
Table of Contents
Summary #
Introduction #
조혈모세포(hematopoietic) 관련 마커로 luminal에선 GATA3, TNBC에선 BCL11A
Results #
BCL11A is highly expressed in triple-negative breast cancer #
High levels of BCL11A promote tumour development #
Knockdown of BCL11A reduces tumourigenicity of TNBC cells #
Bcl11a is required for the development of DMBA tumours #
Bcl11a is required for the maintenance of DMBA tumours #
Bcl11a is required for mammary stem and progenitor cells #
Disscussion #
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