Transcription factor BCL11A가 TNBC에서 과발현되거나 증폭됨. 이는 tumor formation을 촉진하는 반면, 이것의 knockdown은 암을 저해함.

Summary #

Introduction #

조혈모세포(hematopoietic) 관련 마커로 luminal에선 GATA3, TNBC에선 BCL11A

Results #

BCL11A is highly expressed in triple-negative breast cancer #

METABRIC, TCGA에서 봤을 때 과발현됨.

High levels of BCL11A promote tumour development #

Knockdown of BCL11A reduces tumourigenicity of TNBC cells #

Bcl11a is required for the development of DMBA tumours #

Bcl11a is required for the maintenance of DMBA tumours #

Bcl11a is required for mammary stem and progenitor cells #

Disscussion #

Incoming Links #

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