Summary #

Introduction #

Results #

Inference of Cancer Genome Evolution #

Modeling Clonal and Subclonal Mutation Clusters #

Subclonal Loss of Multiple Chromosomes in PD4120a #

Integrating Subclonal Point Mutations and Copy Number Changes #

Phasing Pairs of Subclonal Somatic Mutations #

A Phylogenetic Tree for PD4120a #

Timing Chromosomal Evolution in 20 Breast Cancer Genomes #

Changing Spectrum of Mutations over Time #

Timing Kataegis, Localized Clusters of Mutations #

Dominant Subclones Are Always Present in Breast Cancers #

Discussion #

A Model of Breast Cancer Development #

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