PIC has become the most widely applied formula for genetic studies to measure the information content of molecular markers.

마커의 heterozygosity는 개체별로 해당 좌위가 hetero한지를 설명함

$$ H = 1 - \sum\limits_{i = 1}^{l} {P_{i}^{2} } $$

마커의 PIC는 집단내에서 얼마나 다형인지를 설명함 - 마커의 검정력

$$ {\mathbf{PIC}} = 1 - \sum\limits_{i = 1}^{l} {\mathop P\nolimits_{i}^{2} } - \sum\limits_{i = 1}^{l - 1} {\sum\limits_{j = i + 1}^{l} 2 } \mathop P\nolimits_{i}^{2} \mathop P\nolimits_{j}^{2} = 1 - \sum\limits_{i = 1}^{l} {\mathop P\nolimits_{i}^{2} } - \left( \sum\limits_{i = 1}^{l} {\mathop P\nolimits_{i}^{2} } \right)^{2} + \sum\limits_{i = 1}^{l} {\mathop P\nolimits_{i}^{4} } $$

관련논문

• PICcalc: An Online Program to Calculate Polymorphic Information Content for Molecular Genetic Studies Biochemical Genetics 2012-10-??

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