Mitogen-activated protein kinase kinase kinase 1

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including Insulin (MIM 176730) and many Growth factors. (http://en.wikipedia.org/wiki/MAP3K1)

Mouse genetics has revealed that the kinase is important in: correct Embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.

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