Summary #

Introduction #

Materials and Methods #

Bioinformatics analysis #

Project Achilles #

Cells #

Gene knockdown #

Cell based assays #

Results #

Identification of gene amplifications in TCGA datasets #

Identification of amplified cancer genes with putative cancer driver activity #

DCUN1D1 as a novel amplified cancer gene #

Epigenetic regulators amplified in TCGA datasets #

Discussion #

Metabolic cancer amplified genes #

Epigenetic cancer amplified genes #

Ubiquitin-like modifiers #

MAP kinase pathway #

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