Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes).

RNA-seq 등으로 얻은 Gene expression DEG 결과가 어떤 gene set과 유의하게 연관되어 있는지 알려줌

Fisher's exact test로 우연히 그 gene set에 포함되지 않음을 유의한 정도로 표시함. gene set 정보는 MSigDB에서 가져온다.

결과 예제

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