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The topography of mutational processes in breast cancer genomes #
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Summary #

Introducation #

Results #

Diverse temporal relationships with replication #

Direction of replication influences mutational distribution #

Subtype heterogeneity in breast cancer and mutation distribution #

Processive mutagenesis #

Transcriptional strand biases #

Mutation signatures and nucleosome occupancy #

Discussion #

Methods #

Data set #

Replication analyses #

Choice of reference cell line for mutational distribution #

Transcriptional strand characterization #

Computing replication and transcription strand ratio #

Processivity #

Relationships with nucleosome occupancy #

Other computational and statistical analyses #

Suggested Pages #

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