Summary #

JARID1B, Histone H3K4 demethylase is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast breast results in the gain of unique chromatin binding and luminal expression and splicing patterns.

Introduction #

Results #

JARID1B is amplified and overexpressed in breast tumors #

Loss of JARID1B inhibitis breast cancer cell growth #

Loss of JARID1B-induced gene expression changes #

TGF beta signaling pathway in JARID1B-loss-mediated growth arrest #

Genomic targets of JARID1B #

JARID1B binding pattern overlaps with H2K4me3 and active genes #

JARID1B binding is enriched in luminal-high genes #

Clinical relevance of JARID1B activity in breast cancer #

JARID1B and CTCF interaction #

JARID1B mutant with luminal gain-of-function #

Discussion #

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