Summary #

Introduction #

Results #

Differences in Gene Essentiality Reflect the Distinguishing Characteristics of AML Cell Lines #

Correlated Gene Essentiality across Cell Lines Reveals Functional Gene Relationships #

C1orf27 Interacts with UFSP2 and Is Required for deUFMylation #

C17orf89 Is an Assembly Factor for Mitochondrial Complex I #

Identification of Driver Oncogenes Using an Integrative Genomic Approach #

Two Independent Screening Approaches Reveal Common Synthetic Lethal Interactions with Oncogenic Ras #

MAPK Pathway Activation Requires PREX1 in Mutant Ras AML Cells #

Lack of Paralog Expression Explains AML-Specific Dependence on PREX1 #

Discussion #

An Integrative Genomic Approach Reveals Oncogene Dependency #

Functional Gene Network Mapping Using Correlated Gene Essentiality Analysis #

Screens in Established Human AML and Engineered Mouse Cell Lines Uncover a Common Set of Ras Synthetic Lethal Interactions #

Design of Synthetic Lethal Screens and sgRNA Libraries #

General Comments on Synthetic Lethality in Cancer #

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