Extrachromosomal DNA (Cytoplasmic DNA, ecDNA) is any DNA that is found outside of the nucleus of a Cell. Most DNA in an individual genome is found in Chromosomes but DNA found outside of the nucleus also serves important biological functions. (https://en.wikipedia.org/wiki/Extrachromosomal_DNA)
- Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity Nature : 17개 암종에서 ecDNA 확인함. 약 50%의 암에서 ecDNA가 발견됨. 정상에서는 발견 안됨. Driver Oncogene이 그 안에 있음.