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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups #
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주요 내용 #

Breast cancer와 관련된 Genomic (CNV) Transcriptomic (Gene expression) 유전자변화 종합 분석하고, 그룹화

This data are shared on behalf of METABRIC.

A breast cancer population genomic resource #

Genome variation affects tumor expression architecture #

Expression outliers refine the breast cancer landscape #

Trnas-acting association reveal distinct modules #

Integrative clustering reveals novel subgroups #

Pathway deregulation in the integrative subgroups #

Discussion #

Supplement #

8. Segmentation and copy number alteration calling using CBS #

Normalisation of intensities #

Calling of copy number alterations and adjustment for tumour cellularity #

Identification of germline CNVs #

Gene-centric alterations #

Probe-level alterations #

Measures of genomic instability #

Identification of recurrent alterations #

9. Segmentation and copy number alteration calling using HMM #

Normalisation of intensities #

6-state HMM for segmentation and discrete copy number prediction in normals #

HMM-Dosage for segmentation and discrete copy number prediction in tumors #

Gene-centric alterations #

10. Comparison of segmentation methods based on MPLA #

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