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Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Mutations of this gene are a step in the development of many Cancers. PTEN orthologs have been identified in most mammals for which complete genome data are available. (WikiPedia)

Tumor suppressor gene, PTEN encodes a lipid phosphatase that is an important negative regulator of PI3K-Akt signaling pathway