Global transcription network incorporating distal regulator binding reveals selective cooperation of cancer drivers and risk genes
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Summary #
Introduction #
Meterials and Methods #
Data sets used for network construction #
Network construction #
Prior evaluation #
Subclass analysis #
Drug response matrix #
Expression perturbation #
Identification and analysis of transcriptional drivers and risk genes #
Results #
Prior framework construction and its evaluation #
Global network construction and prior evaluation #
Clinical evaluation of the global network #
Biological implications of distal regulation in the global network #
Network analysis of transcriptional drivers and risk genes #
Role of DNA variations in the cooperation of drivers and risk genes #
Discussion #
Suggested Pages #
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