Summary #

Introduction #

Meterials and Methods #

Data sets used for network construction #

Network construction #

Prior evaluation #

Subclass analysis #

Drug response matrix #

Expression perturbation #

Identification and analysis of transcriptional drivers and risk genes #

Results #

Prior framework construction and its evaluation #

Global network construction and prior evaluation #

Clinical evaluation of the global network #

Biological implications of distal regulation in the global network #

Network analysis of transcriptional drivers and risk genes #

Role of DNA variations in the cooperation of drivers and risk genes #

Discussion #

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