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Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology #
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Structured data

About
Triple-negative breast cancer
Date Published
Publisher
Modern Pathology

Summary #

Introduction #

Meterials and methods #

Patient Selection #

Clinicopathological Review #

Immunohistochemistry for Androgen Receptor #

DNA Extraction #

The MSK-IMPACT Assay #

Mutation Significance Analysis #

Sanger Sequencing #

Statisticl Analysis #

Results #

Clinicopathologic Characteristics of the Patients #

Immunohistochemistry #

Somatic Mutations and Copy Number Alterations #

Genetic Alterations by Histologic Subtypes and Morphologic Features #

Triple Negative Breast Cancer Not Otherwise Specified #

Triple Negative Breast Cancer with Apocrine Differentiation #

Metaplastic Carcinoma #

Triple Negative Breast Cancer with a Large Central Acellular Zone #

Tumors with Prominent Tumor-infiltrating Lymphocytes #

Genetic Alterations in BRCA1 Germline Mutation Carriers #

Discussion #

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