DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. (https://en.wikipedia.org/wiki/DNA-PKcs)
NHEJ에 관여함.
ATM과 Syntethic lethality 관계에 있음. 따라서, ATM 변이 암 환자에게 DNA-PKcs inhibitor를 약으로 처방할 수 있음
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