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Cell signaling #
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Cell signalling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions.

  1. Extracellular signals determine whether a cell lives or dies, or whether it remains quiescent or is stimulated to perform its specific function.
  2. Intercellular signaling is clearly importent in the developing embryo, and in maintaining tissue organization.

Classified into several groups

  1. Dogma to neighboring cells and pathogens.
  2. Contact with neighboring cells, mediated through adhesion molecules and/or gap functions.
  3. Contact with ECM, mediated through integrins.
  4. Secreted molecules.
  5. Paracrine signaling.
  6. Autocrene signaling.
  7. Synaptic signaling.
  8. Endocrine signaling.

Cellular receptors

  1. Receptors associated with kinase activity
  2. Receptor tyrosine kinase
  3. No intrinsic catalytic activity receptor
  4. G protein coupled receptor
  5. Nuclear receptor
  6. Other cless receptor (Notch, Wnt-b-catenin signaling)