A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies
#
Find similar titles
- (rev. 4)
- Hyungyong Kim
Structured data
- About
- Horse
- SNP array
- Date Published
- Publisher
- PLOS Genetics
- URL
- http://www.ncbi.nlm.nih.gov/pubmed/22253606
Table of Contents
Summary #
Introduction #
말(Horse)은 5000년 이상 인류의 문명화에 함께 해 왔다. 400 이상의 품종이 구분되어 있다.
Horse genome has 2.67 Gb, and 96% assembled.
EquineSNP50 BeadChip으로 타이핑.
Results #
SNP array properties, polymorphism, and genome coverage in the domestic horse (Equus caballus) #
14개의 서로 다른 품종에서 354 개체 genotyping, 3 개체는 실패. 8 쌍의 동일 시료를 포함하여, 각 시료가 완전 매치함을 확인. 18 trio에서 15의 멘델 유전 확인.
54,602 SNPs에서 53,524개 validated. 53,066 were polymorphic (MAF>0.001).
Average spacing between functional SNPs was 43.1 kb.
Utility of the EquineSNP50 BeadChip in extant Perissodactyla #
진화적으로 관련된 18개 생물종 (기제목, Perissodactyla, 코뿔소, 말 등)으로 부터 53 개체 genotyping. 그 가운데 zebra는 완전 실패함.
Minor allele frequency and genetic diversity within and across domestic horse breeds #
Genome-wide linkage disequilibrium analysis within and across domestic horse breeds #
Inbreeding, genetic distance, and relationships between domestic horse breeds #
Relationships between the domestic horse and extant Hippomorpha #
Application to genome-wide association studies (GWAS) #
Discussion #
Properties of the EquineSNP50 BeadChip #
Genetic diversity, inbreeding, and LD in the domestic horse #
Relationships between domestic horse breeds #
Relationship between the domestic horse and other Hippomorpha #
Concluding statement #
Meterials and Methods #
Design of the EquineSNP50 BeadChip #
Horses #
Samples from other Perissodactyla #
SNP summary statistics #
Additional data filtering in extant Perissodactyla #
Genome-wide linkage disequilibrium #
Relationship between breeds and genetic structure in the domestic horse #
Estimation of inbreeding #
Relationship among the domestic horse breeds and the Prezwalski’s horse #
Relationship among the extant equids and the domestic horse #
Mapping of coat color loci #
Haplotypes at coat color loci #
Suggested Pages #
- 0.025 GWAS
- 0.025 HDF5
- 0.025 Copy-number variation
- 0.025 ClusterCall
- 0.025 Relational database
- 0.025 May 31
- 0.025
- 0.025
- 0.025
- 0.025 PennCNV
- More suggestions...